The vertebrate spleen has important functions in immunity and haematopoiesis, many of which have been well studied. In contrast, we know much less about the mechanisms governing its early embryonic development. However, as a result of work over the past decade‐mostly using knockout mice–‐significant progress has been made in unravelling the genetic processes governing the spleen's early development. Key genetic regulators, such as Tlx1 and Pbx1, have been identified, and we know some of the early transcriptional hierarchies that control the (...) early patterning and proliferation of the splenic primordium. In mouse and humans, asplenia can arise as a result of laterality defects, or the spleen can be absent with no other discernible abnormalities. Surprisingly, given the spleen's diverse functions, asplenic individuals suffer no major haematopoietic or immune defects apart from a susceptibility to infection with encapsulated bacteria. Recent evidence has shed light on a previously unknown role of the spleen in the development and maintenance of specific B cell populations that are involved in the initial response to infection caused by encapsulated bacteria. The lack of these populations in asplenic mice and humans may go some way to explaining this susceptibility. BioEssays 29: 166–177, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The human Y chromosome contains very low levels of nucleotide variation. It has been variously hypothesized that this invariance reflects historic reductions in the human male population, a very recent common ancestry, a slow rate of molecular evolution, an inability to evolve adaptively, or frequent selective sweeps acting on genes borne on the Y chromosome. We propose an alternative theory in which human Y chromosome evolution is driven by mutations in the maternally inherited mitochondrial genome, which impair male fertility and (...) ultimately lead to a reduction in the effective population size (Ne) and consequently the variability of the Y chromosome. BioEssays 24:275–279, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10062. (shrink)

Michael Slote has long been one of the foremost contributors to discussions in moral theory. Both his work on consequentialism and his particular version of virtue ethics have been highly influential. In recent years, Slote has developed a distinctive and original voice, placing his various theoretical endeavours under the title of “sentimentalism”. His key ethical work in this context is Moral Sentimentalism, which, uniquely, defends versions of both a metaethical and aretaic sentimentalist theory. The present volume is an extended discussion (...) of that work, containing eight original commentaries and a substantial response by Slote, which provide fresh insights into his position. The collection will be of significant value to anyone interested in contemporary debates in meta-ethics or normative ethics. (shrink)

Most philosophers think that phenomenal consciousness underlies, or at any rate makes a large contribution, to moral considerability. This paper argues that many such accounts invoke question-begging arguments. Moreover, they’re unable to explain apparent differences in moral status across and within different species. In the light of these problems, I argue that we ought to take very seriously a view according to which moral considerability is grounded in functional properties. Phenomenal consciousness may be sufficient for having a moral value, but (...) it may not be necessary, and it may contribute relatively little to our overall considerability. (shrink)

On his death in 2007, Richard Rorty was heralded by the New York Times as “one of the world’s most influential contemporary thinkers.” Controversial on the left and the right for his critiques of objectivity and political radicalism, Rorty experienced a renown denied to all but a handful of living philosophers. In this masterly biography, Neil Gross explores the path of Rorty’s thought over the decades in order to trace the intellectual and professional journey that led him to that (...) prominence. The child of a pair of leftist writers who worried that their precocious son “wasn’t rebellious enough,” Rorty enrolled at the University of Chicago at the age of fifteen. There he came under the tutelage of polymath Richard McKeon, whose catholic approach to philosophical systems would profoundly influence Rorty’s own thought. Doctoral work at Yale led to Rorty’s landing a job at Princeton, where his colleagues were primarily analytic philosophers. With a series of publications in the 1960s, Rorty quickly established himself as a strong thinker in that tradition—but by the late 1970s Rorty had eschewed the idea of objective truth altogether, urging philosophers to take a “relaxed attitude” toward the question of logical rigor. Drawing on the pragmatism of John Dewey, he argued that philosophers should instead open themselves up to multiple methods of thought and sources of knowledge—an approach that would culminate in the publication of Philosophy and the Mirror of Nature , one of the most seminal and controversial philosophical works of our time. In clear and compelling fashion, Gross sets that surprising shift in Rorty’s thought in the context of his life and social experiences, revealing the many disparate influences that contribute to the making of knowledge. As much a book about the growth of ideas as it is a biography of a philosopher, Richard Rorty will provide readers with a fresh understanding of both the man and the course of twentieth-century thought. (shrink)

It is an interesting fact of our time that some of the best studies of communism and Marxism have been written by Catholic scholars. This book, based on a series of television programs in St. Louis aims at presenting an historical and theoretical understanding of the emergence of Marxism and the development of Communism. Written for the intelligent lay reader as an introduction to a complex subject, the treatment is lucid and balanced.—R. J. B.

The rightness and wrongness of actions fits on a continuous scale. This fits the way we evaluate actions chosen among a diverse range of options, even though English speakers don’t use the words “righter” and “wronger”. I outline and defend a version of scalar consequentialism, according to which rightness is a matter of degree, determined by how good the consequences are. Linguistic resources are available to let us truly describe actions simply as right. Some deontological theories face problems in accounting (...) for degrees of rightness, as they don't invoke continuous parameters among the right-making features of action. (shrink)

> I read the two papers you sent me and found the Budapest one particularly > clear. But I have two reservations concerning your scheme. The first is > that I don?t understand why one needs collapse, and the second is that the > collapsing scheme seems so complicated. Perhaps it is best to illustrate > using an example.

Some philosophers (including Urmson, Humberstone, Shah, and Velleman) hold that believing that p distinctively involves applying a norm according to which the truth of p is a criterion for the success or correctness of the attitude. On this view, imagining and assuming differ from believing in that no such norm is applied. I argue against this view with counterexamples showing that applying the norm of truth is neither necessary nor sufficient for distinguishing believing from imagining and assuming. Then I argue (...) that the different functional properties of these mental states are enough to distinguish them, and that norm-application doesn't help us draw the functional distinctions. (shrink)

In a recent paper in this journal, Joshua Blanchard has identified a novel problem: the problem of unwelcome epistemic company. We find ourselves in unwelcome epistemic company when we hold a belief that is also held mainly or most prominently by those we regard as morally or epistemically bad. Blanchard argues that some, but not all, unwelcome epistemic company provides higher-order evidence against our belief. But he doesn't provide a test for when company is unwelcome or a diagnosis of why (...) it is unwelcome. I provide both. On my disjunctive test, unwelcome epistemic company provides us with a defeater when either there is a match between the content of the belief and the properties that make our company unwelcome, or there is reason to suspect that the belief arose via a shared, unreliable, causal process. (shrink)

Frankfurt-style cases are widely taken to show that agents do not need alternative possibilities to be morally responsible for their actions. Many philosophers take these cases to constitute a powerful argument for compatibilism: if we do not need alternative possibilities for moral responsibility, it is hard to see what the attraction of indeterminism might be. I defend the claim that even though Frankfurt-style cases establish that agents can be responsible for their actions despite lacking alternatives, agents can only be responsible (...) if they possess certain powers, and possession of these powers is - arguably - incompatible with determinism. Because this is the case, Frankfurt-style cases fail to advance the debate between compatibilism and incompatibilism. (shrink)

I argue that evolutionary debunking arguments are dialectically ineffective against a range of plausible positions regarding moral truth. I first distinguish debunking arguments which target the truth of moral judgements from those which target their justification. I take the latter to rest on the premise that such judgements can be given evolutionary explanations which do not invoke their truth. The challenge for the debunker is to bridge the gap between this premise and the conclusion that moral judgements are unjustified. After (...) briefly discussing older attempts to bridge this gap, I focus on Joyce’s recent attempt, which rests on the claim that ‘we do not have a believable account of how moral facts could explain the mechanisms and forces which give rise to moral judgements’. I argue that whether or not there is such an account depends on what it is permissible to assume about moral truth in this context. Further, I suggest that it is reasonable to make assumptions about moral truth which allow for the possibility of at least partial moral epistemologies. The residual challenge for the debunker is to show that these assumptions are unreasonable in a way which doesn’t render their debunking argument superfluous. (shrink)

There's heated debate around whether people who did terrible things in the past, at a time when there was widespread acceptance of such actions, are appropriately blamed by us, on the grounds they weren't really morally ignorant, or their ignorance was itself culpable. I point to puzzles that arise if we blame them. We need to explain how they could act so badly if they weren't fully ignorant. I argue that plausible answers to that question entail that they're not blameworthy, (...) or that we lack standing to blame them. (shrink)

consistent and sufficiently strong system of first-order formal arithmetic fails to decide some independent Gödel sentence. We examine consistent first-order extensions of such systems. Our purpose is to discover what is minimally required by way of such extension in order to be able to prove the Gödel sentence in a non-trivial fashion. The extended methods of formal proof must capture the essentials of the so-called ‘semantical argument’ for the truth of the Gödel sentence. We are concerned to show that the (...) deflationist has at his disposal such extended methods—methods which make no use or mention of a truth-predicate. This consideration leads us to reassess arguments recently advanced—one by Shapiro and another by Ketland—against the deflationist's account of truth. Their main point of agreement is this: they both adduce the Gödel phenomena as motivating a ‘thick’ notion of truth, rather than the deflationist's ‘thin’ notion. But the so-called ‘semantical argument’, which appears to involve a ‘thick’ notion of truth, does not really have to be semantical at all. It is, rather, a reflective argument. And the reflections upon a system that are contained therein are deflationarily licit, expressible without explicit use or mention of a truth-predicate. Thus it would appear that this anti-deflationist objection fails to establish that there has to be more to truth than mere conformity to the disquotational T-schema. (shrink)

I argue that one intends that ϕ if one has a desire that ϕ and an appropriately related means-end belief. Opponents, including Setiya and Bratman, charge that this view can't explain three things. First, intentional action is accompanied by knowledge of what we are doing. Second, we can choose our reasons for action. Third, forming an intention settles a deliberative question about what to do, disposing us to cease deliberating about it. I show how the desire- belief view can explain (...) why these phenomena occur when they occur, and why they don't when they don't. (shrink)

I present a novel objection to fine-tuning arguments for God's existence. On any values of the physical constants, the psychophysical laws could be set to permit intelligent and happy beings, so the specific values of the physical constants in our world provide little evidence for God's existence. For example, even if the physical constants didn't allow carbon or any atoms larger than hydrogen, the psychophysical laws could be set so that charge is sufficient to realize romantic desire. Then every hydrogen (...) atom would be a proton and electron in love. (shrink)

In the literature over the Ramsey-sentence approach to structural realism, there is often debate over whether structural realists can legitimately restrict the range of the second-order quantifiers, in order to avoid the Newman problem. In this paper, I argue that even if they are allowed to, it won’t help: even if the Ramsey sentence is interpreted using such restricted quantifiers, it is still an implausible candidate to capture a theory’s structural content. To do so, I use the following observation: if (...) a Ramsey sentence did encode a theory’s structural content, then two theories would be structurally equivalent just in case they have logically equivalent Ramsey sentences. I then argue that this criterion for structural equivalence is implausible, even where frame or Henkin semantics are used. (shrink)

Ethical reductionism is the best version of naturalistic moral realism. Reductionists regard moral properties as identical to properties appearing in successful scientific theories. Nonreductionists, including many of the Cornell Realists, argue that moral properties instead supervene on scientific properties without identity. I respond to two arguments for nonreductionism. First, nonreductionists argue that the multiple realizability of moral properties defeats reductionism. Multiple realizability can be addressed in ethics by identifying moral properties uniquely or disjunctively with properties of the special sciences. Second, (...) nonreductionists argue that irreducible moral properties explain empirical phenomena, just as irreducible special-science properties do. But since irreducible moral properties don't successfully explain additional regularities, they run the risk of being pseudoscientific properties. Reductionism has all the benefits of nonreductionism, while also being more secure against anti-realist objections because of its ontological simplicity. (shrink)

In this paper I state and reject two of the most commonly given arguments for regulating access by insurance companies to the results of genetic tests. I then argue that since we cannot assume a priori that those genetically predisposed to disease will have worse health outcomes than those not so disposed, we cannot know a priori that genetic discrimination will emerge as a major problem in a free market health insurance system. Finally, I explore the possibility of a free-market (...) solution to the problem of genetic discrimination:genetic insurance. (shrink)

In applied ethics, debates about responsibility have been relentlessly individualistic and synchronic, even as recognition has increased in both philosophy and psychology that agency is distributed across time and individuals. I therefore warmly welcome Brown and Savulescu’s analysis of the conditions under which responsibility can be shared and extended. By carefully delineating how diachronic and dyadic responsibility interact with the long-established control and epistemic conditions, they lay the groundwork needed for identifying how responsibility may be inter-individual and intra-individual. Unsurprisingly, I (...) don’t agree with every aspect of their rich account. I strongly suspect that the privileged place the individual continues to occupy in their taxonomy is a residue of the kind of internalist intuitions which dominate WEIRD thinking.1 2 However, I won’t pursue this line of thought here. Instead, I apply Brown and Savulescu’s analysis. Moving beyond the programmatic level at which they develop their account, I will show how it provides a basis for excusing many individuals, focusing not on the dyadic level but the diachronic. Most of the …. (shrink)

It is very widely held that Frankfurt-style cases—in which a counterfactual intervener stands by to bring it about that an agent performs an action but never actually acts because the agent performs that action on her own—show that free will does not require alternative possibilities. This essay argues that that conclusion is unjustified, because merely counterfactual interveners may make a difference to normative properties. It presents a modified version of a fake barn case to show how a counterfactual intervener can (...) make the difference between an agent knowing a fact or merely truly believing that fact, by eliminating veretic epistemic luck. If counterfactual interveners can make this kind of difference to the epistemic status of agents, the essay argues, there is no reason why they can't make an analogous difference to agents' moral responsibility. It concludes that reflection on these cases reveals that despite the mountains of words spilled on the topic, we still don't fully understand what role access to alternative possibilities plays in whether or not agents are morally responsible for their actions. (shrink)

Several ethicists have argued that research trials and treatment programs that involve the provision of drugs to addicts are prima facie unethical, because addicts can’t refuse the offer of drugs and therefore can’t give informed consent to participation. In response, several people have pointed out that addiction does not cause a compulsion to use drugs. However, since we know that addiction impairs autonomy, this response is inadequate. In this paper, I advance a stronger defense of the capacity of addicts to (...) participate in the programs envisaged. I argue that it is only in certain circumstances that addicts find themselves choosing in ways that conflict with their genuine preferences. Research and treatment programs have none of the features that characterize choices in these autonomy-undermining circumstances, and there is therefore no reason to think that addicts lack the capacity to give informed consent to these programs. (shrink)

We are all apt to alter our beliefs and even our principles to suit the prevailing winds. Examples abound in public life, but we are all subject to similar reversals. We often accuse one another of hypocrisy when these kinds of reversals occur. Sometimes the accusation is justified. In this paper, however, I will argue that in many such cases, we don’t manifest hypocrisy, even if our change of mind is not in response to new evidence. Marshalling evidence from psychology (...) and evolutionary theory, I will suggest that we are designed to update our beliefs in response to social signals: as these signals change, we change our minds, often without even noticing. (shrink)

I argue that if David Lewis’ modal realism is true, modal realists from different possible worlds can fall in love with each other. I offer a method for uniquely picking out possible people who are in love with us and not with our counterparts. Impossible lovers and trans-world love letters are considered. Anticipating objections, I argue that we can stand in the right kinds of relations to merely possible people to be in love with them and that ending a trans-world (...) relationship to start a relationship with an actual person isn't cruel to one's otherworldly lover. (shrink)

The novice/expert problem is the problem of knowing which apparent expert to trust. Following Alvin Goldman’s lead, a number of philosophers have developed criteria that novices can use to distinguish more from less trustworthy experts. While the criteria the philosophers have identified are indeed useful in guiding expert choice, I argue, they can’t do the work that Goldman and his successors want from them: avoid a kind of testimonial scepticism. We can’t deploy them in the way needed to avoid such (...) scepticism, because it would take genuine expertise to do so. I argue that attempts to deploy them in this sort of deep way involve a kind of transgression akin to, and at least as unreliable as, epistemic trespassing. We should give up trying to solve the novice/expert problem and instead promote better epistemic trust. (shrink)

We can infer moral conclusions from nonmoral evidence using a three-step procedure. First, we distinguish the processes generating belief so that their reliability in generating true belief is statistically predictable. Second, we assess the processes’ reliability, perhaps by observing how frequently they generate true nonmoral belief or logically inconsistent beliefs. Third, we adjust our credence in moral propositions in light of the truth ratios of the processes generating beliefs in them. This inferential route involves empirically discovering truths of the form (...) “Process P, which generates belief in moral proposition M, has truth ratio T", and using them to discover probabilities for moral propositions. The inferential route is noncircular, and progress along it is driven fundamentally by induction. (shrink)

All parties to the proceedings that follow concur with DS. The question is whether there is anything more to truth than can be gleaned from DS alone. Deflationism holds that there is nothing more to truth than this. Now it would appear that 'warrantedly assertible' can play the role of T in DS. Hence it would appear that the deflationist would be able to identify truth with warranted assertibility.

Janna Thompson has outlined ‘the apology paradox’, which arises whenever people apologize for an action or event upon which their existence is causally dependent. She argues that a sincere apology seems to entail a wish that the action or event had not occurred, but that we cannot sincerely wish that events upon which our existence depends had not occurred. I argue that Thompson’s paradox is a backward-looking version of Parfit’s (forward-looking) ‘non-identity problem’, where backward- and forward-looking refer to the perspective (...) of an agent apologizing for or contemplating an action. The temporal perspective of the agent gives us the tools with which to dissolve the air of paradox which surrounds these problems. Each is best grasped from one temporal perspective, but the para- doxes arise when we attempt to examine it simultaneously from another. The evaluations appropriate to the apology paradox and the non-identity problem are therefore time-indexed. (shrink)

This paper elaborates and defends an expressivist account of the claims of mind-independence embedded in ordinary moral thought. In response to objections from Zangwill and Jenkins it is argued that the expressivist 'internal reading' of such claims is compatible with their conceptual status and that the only 'external reading' available doesn't commit expressivisists to any sort of subjectivism. In the process a 'commitment-theoretic' account of the semantics of conditionals and negations is defended.

Nietzsche holds that one should believe what best promotes life, and he also accepts the correspondence theory of truth. I’ll call this conjunction of views Nietzschean pragmatism. This article provides textual evidence for attributing this pragmatist position to Nietzsche and explains how his broader metaethical views led him to it.The following section introduces Nietzschean pragmatism, discussing how Nietzsche expresses it in BGE, and distinguishing it from William James’s pragmatism about truth. The second section explains how Nietzsche’s skepticism about values that (...) can’t be grounded in individual passion attracted him to this kind of pragmatism. The third section explores an early application of Nietzschean... (shrink)